There was no way through for Chelsea as Watford halted their recent resurgence in a goalless Premier League stalemate at Vicarage Road while Everton piled more woe on Newcastle United with a 3-0 victory on Wednesday.
Barcelona's Lionel Messi and Luis Suarez secured victory over nine-man Atletico Madrid in La Liga's top of the table clash, while Juventus won a 12th straight Serie A game to stay hot on the heels of leaders Napoli.
Chelsea captain John Terry will leave the Premier League champions when his contract expires at the end of the season, he told British media on Sunday.
Aston Villa were relegated from the Premier League for the first time since it began in 1992 when they suffered their 24th loss of the season in a 1-0 defeat at Old Trafford on Saturday.
Manchester City's hopes of closing the gap on the Premier League pacesetters were frustrated as they were held to a 1-1 draw at home to lowly West Bromwich Albion on Tuesday.
Liverpool, level on points with Manchester United, can add to the pressure if they take three points at West Ham United in Saturday's lunchtime kickoff.
Leicester go five clear after win at Everton
Arsenal ended their seven match winless run in the Premier League with a surprise 3-1 London derby victory over Chelsea at the Emirates Stadium on Saturday while Manchester United were held to a 2-2 draw at Leicester City.
Ole Gunnar Solskjaer's side, who had won their last ten away games in the Premier League, stay third on 27 points, a point behind second-placed Leicester.
Chelsea moved into the Premier League's top four as Mason Mount's superb first-half goal earned them a 1-0 win at champions Liverpool who suffered a club-record fifth straight home league defeat on Thursday.
Chelsea ended their slump with a win over Arsenal while seemingly invincible Manchester City lost their 100 per cent record to West Ham United on a day of contrasting fortunes for the Premier League title favourites on Saturday.
Champions Liverpool are five points clear at the top of the Premier League after a 7-0 away hammering of Crystal Palace while Arsenal's troubles continued with a 2-1 defeat at second-placed Everton on Saturday.
Manchester United and Manchester City must switch their focus from the Champions League to the Premier League when they meet at Old Trafford on Sunday in a derby that Louis van Gaal says will show whether United are true title contenders.
Manchester City stayed ahead of age-old local rivals Manchester United at the top of the Premier League on Saturday with a deserved 1-0 win away to champions Chelsea.
Arsenal must not rest on their laurels after successive FA Cup victories and instead use one of the side's 'best squads' to inspire them to Premier League glory next season.
Leicester City recorded the biggest ever English top-flight away win by beating 10-man Southampton 9-0 at a rain-sodden St Mary's to move up to second place in the Premier League on Friday.
Champions Liverpool were ripped apart 7-2 at Aston Villa and Manchester United were humiliated 6-1 at home by Tottenham Hotspur on Sunday in one of the most astonishing days of Premier League results.
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Arsenal midfielder Jack Wilshere will be out of action for three months after undergoing ankle surgery, the Premier League club said on Thursday.
A last-gasp Christian Benteke penalty handed Tim Sherwood his first win as Aston Villa manager.
Manchester United manager David Moyes has suffered a stuttering start to life at Old Trafford but it could have been far worse for the Scot if he had failed to retain the services of striker Wayne Rooney.
London clubs' erratic start to the Premier League season improved with victories for Chelsea, Tottenham Hotspur and Arsenal on Saturday but Manchester sides continued to make the running, with City and United the top two.
How quickly affections can switch in soccer. Where once they would serenade coach Jose Mourinho at Stamford Bridge with an operatic flourish, now Chelsea fans have fallen headlong for another man driving them inexorably to the Premier League title.
The fixture list suggests that Chelsea should still be able to finish above challengers Tottenham Hotspur. But strange things can happen when the pressure reaches it's greatest intensity and here was certainly something strange about Chelsea at Old Trafford on Sunday.
There may be little glamour in being a mid-table Premier League team but this season suggests that those clubs who become bored with such an existence can find the alternative is far worse.
Manchester United's struggle to achieve a top-four finish continued on Tuesday as Zlatan Ibrahimovic came to their rescue with an added time penalty to salvage a 1-1 draw against Everton in their Premier League clash at Old Trafford.
IMAGES from the English Premier League matches played on Saturday
The English Premier League has not played any matches since March 9 due to the coronavirus pandemic but with UEFA having set a deadline of May 25 for leagues to inform them of their re-start plans, the clubs are actively seeking a way to resume the 2019-20 season and finish the remaining nine games. Doing so would ensure they avoid potential financial penalties from broadcasters, crown the champions and decide the questions of European qualification and relegation. The league will hold a meeting with all 20 clubs on Friday and say they are evaluating a number of scenarios - so what are the options?
Chelsea beat Newcastle United 2-0 for a 10th successive Premier League home win at their Stamford Bridge stronghold on Saturday to reassert themselves as Premier League leaders while champions Manchester City drew at Everton.
Frank Lampard could make an emotional appearance against former club Chelsea this weekend as his new employers Manchester City host Jose Mourinho's side in an early showdown between the Premier League's heavyweights. Catch all the action.
Arsenal's improbable late run at the Premier League title gained momentum with a 1-0 victory at struggling Burnley on Saturday, an eighth straight triumph that moved them within four points of leaders Chelsea.
Manchester United's early season problems were compounded by a humiliating 4-0 loss to third-tier Milton Keynes Dons in the League Cup second round on Tuesday leaving new manager Louis van Gaal still looking for his first win.
Bitter rivals Arsene Wenger and Jose Mourinho had wildly contrasting afternoons on Saturday as Arsenal went top of the Premier League and champions Chelsea lost again with their manager being sent off.
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Chelsea scrambled a stoppage-time winner to snatch a 1-0 victory over Everton on Saturday, showing their Premier League title mettle by claiming three points when they looked on course to suffer another damaging blow.
Leicester City continued to do their best Houdini impression on Saturday as they escaped the Premier League drop zone for the first time since November while Manchester City went up to second spot with a thrilling win.
Images from the English Premier League matches played across England on Tuesday
However, experienced goalkeeper Joe Hart and Arsenal midfielder Jack Wilshere were both omitted from a squad announced on Wednesday via a social media video featuring young recreational players from around the country shouting out the names.
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Liverpool flirted with what would have been an embarrassing low in their poor start to the season as they were taken to penalties by fourth tier Carlisle United, but came through to reach the League Cup fourth round on Wednesday.
